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Home >> Seal >>O-Rings >> Kalrez O-Rings >> Kalrez Industry Applications >> Life Sciences

Life Science areas such as pharmaceutical, medical packaging and the food and beverage industries require the highest standards of safety, temperature and chemical resistance in production.

To achieve this they need high performance seals that can ensure efficiency and cleanliness. PTFE has been the material of choice. However, PTFE can creep and cold flow, which can lead to a loss of sealing functionality. Kalrez® perfluoroelastomer parts offer the best in class FDA-compliant seals that have elastomeric properties and sealing capabilities.

Kalrez® Perfluoroelastomer (FFKM) parts provide the highest levels of chemical resistance, outstanding thermal & steam resistance and low contamination from extractables for demanding applications in the life sciences sector where FDA compliance is required.

Kalrez® parts deliver optimal sealing solutions through longer seal life versus lower performing elastomers, cleanliness, and high levels of resistance to chemicals and high temperatures. They are resistant to 1800 chemicals and solvents and retain high levels of elasticity and recovery, even after long-term exposure to elevated temperatures. All this results in longer, more effective performance and increased safety and efficiency in production.

Kalrez® Parts include: O-Rings, Sanitary Seals and Custom Parts

Kalrez® Grades for Life Science Applications

Kalrez®  6230 Kalrez® 6221 Kalrez® LS205 Kalrez® LS390 Kalrez® LS222
Available Geometries O-rings and specialty shapes O-rings O-rings and specialty shapes Hygienic Couplings High Volume Specialty Shapes
Color Black White White Grey Black
Rotating equipment (mixers, pumps, centrifuges, etc.)
Filtration & Drying
Flow Regulation (valves)
WFI (water for injection)
Medical packaging
USP <87> & <88> class VI @121°C
Japan Pharmacopeia 
EC 1935/2004 Please contact DuPont for Additional Information.

Kalrez®  for Pharmaceutical Production and Medical Packaging

Data Sheets

Kalrez 6221 Data Sheet

Kalrez 6230 Data Sheet

Kalrez LS205 Data Sheet

Kalrez LS390 Data Sheet

The pharmaceutical and medical packaging industry requires the highest level of safety, cleanliness and efficiency in the production process. Kalrez® parts long seal life improve productivity and process optimization create a safer environment for medical packaging, disposable device handling and as well as creating a safer environment in the day to day running of a pharmaceutical manufacturing facility.

Pharmaceutical manufacturing can often involve the use of aggressive chemicals and high temperatures in the process and because of this Kalrez® parts, with their high temperature and chemical resistance, and long seal life, are the perfect fit for the industry.

Kalrez® is the only elastomer that combines the excellent chemical resistance, including steam cycling, with the cleanliness standards required for pharmaceutical production.

Applications in Pharmaceutical Production Include:

  • Safety Valves
  • Butterfly Valves
  • Mechanical Seals
  • Granulators
  • Sanitary Seals

Applications in Medical Packaging Include:

  • Aerosol rings
  • Microvalves
  • Needle covers
  • Serum stoppers
  • Plungers
  • Infusion hangers



Kalrez® for Food and Beverage

Kalrez® LS390 for Food & Beverage Applications

The food and beverage industry, as a producer of products for consumer consumption, must meet the highest standards of safety and cleanliness.

Due to the nature of the production process, highly reliable and efficient sealing solutions that are resistant to chemicals and temperatures are needed. Kalrez® parts, which are the most chemically resistant elastomers are the ideal solution. They offer longer lasting, resistant and secure seals which also minimize fluid absorption so taste and smells are not carried over between batches of different products.

Applications in Food & Beverage Include:

Modern Factory Production Line
  • Homogenizing equipment
  • Stirrers
  • Sterilization processes
  • Seals for filling equipment
  • O-rings and sanitary gaskets
  • Bottling and filling equipment



Standard Kalrez® O-Ring Compounds

Daemar DMR O-Rings Kalrez

Kalrez® Compounds – 4079

4079 perfluoroelastomer parts are a black, low compression set product for use in many dry and wet semiconductor process environments. It has excellent chemical resistance, good mechanical properties and outstanding thermal stability.


Kalrez® Compounds – 6375

6375 is designed to give outstanding performance in the widest possible range of chemicals and temperatures. This product is an excellent choice for use in acids, bases, amines, steam, ethylene oxide, and many other aggressive chemicals.


Kalrez® Compounds – 7075

7075 is designed for general-purpose use as O-rings or custom sealing components in the chemical and hydrocarbon processing industries. It is a carbon black-filled compound with mechanical properties designed for improved sealing performance in temperature cycling applications. 7075 has improved thermal resistance that extends maximum service temperature to 327 °C (620 F).


Kalrez® Compounds – 0090

0090 perfluoroelastomer parts deliver durable, reliable sealing solutions for applications requiring excellent rapid gas decompression (RGD) properties as well as high hardness and high modulus properties. Some application areas include downhole equipment such as drilling and completion tools as well as industrial equipment including pumps and valves.

Specialty Kalrez® O-Ring Compounds


Kalrez® Spectrum™ – 7375

Kalrez® Spectrum™ 7375 perfluoroelastomer parts are an innovative FFKM product based on a patented crosslinking system for chemical process industry applications where broad chemical and water/steam resistance are needed at elevated temperatures. Kalrez® Spectrum™ 7375 parts exhibit excellent compression set resistance, outstanding physical property retention, and good mechanical strength properties.


Kalrez® Compounds -6380

6380 is a non-black product specifically developed for chemical processes involving hot, aggressive amines. It has also been successfully used in applications involving highly oxidizing chemicals. In addition, it has excellent overall chemical resistance. This cream colored product is easily identifiable when selecting an O-ring material for harsh chemical plant services.


Kalrez® Compounds -7090

7090 is a product for uses requiring higher hardness/higher modulus than more typical applications. Kalrez® 7090 perfluoroelastomer parts are well suited for both static and dynamic applications as well as specific sealing applications requiring extrusion resistance at high temperatures.


Kalrez® Compounds -0040

0040 -is a black product specifically designed for low temperature environments where significant chemical resistance is required. Kalrez® 0040 parts maintain elasticity and seal force at temperatures unattainable by other perfluoroelastomers.




Kalrez® Compound – W240

Kalrez® W240 perfluoroelastomer parts are a black product for photovoltaic wet manufacturing processes requiring a wide range of chemical resistance. W240 provides an excellent combination of properties (resistance to acids/bases) and is the product of choice for wet processes as an upgrade from standard elastomers, i.e., FKM, NBR, EPDM, etc.




Kalrez® is a registered trademark of E.I. du Pont de Nemours and Company or its affiliates












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